TY  - JOUR 
AU  - Liceras-Boillos, Pilar
AU  - García Navas, Rósula Mercedes
AU  - Ginel Picardo, Alicia
AU  - Anta Rodríguez, Begoña
AU  - Pérez Andrés, Martín
AU  - Lillo Delgado, María Concepción
AU  - Gómez Rodríguez, Carmela
AU  - Jimeno García, David
AU  - Fernández Medarde, Alberto
AU  - Baltanás, Fernando C.
AU  - Santos de Dios, Eugenio Miguel
PY  - 2016
SN  - 0950-9232
UR  - http://hdl.handle.net/10366/156419
AB  - [ES]Utilizando un mutante condicional de Sos1 inducible por 4-hidroxitamoxifeno (4OHT), analizamos fibroblastos embrionarios de ratón primarios (MEF) de tipo salvaje (WT), Sos1-KO simple, Sos2-KO y doble Sos1/2 KO con el objetivo de para evaluar la...
AB  - [ENUsing a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we analyzed wild-type (WT), single Sos1-KO, Sos2-KO
and double Sos1/2 KO primary mouse embryonic fibroblasts (MEF) with an aim at evaluating the functional specificity...
LA  - eng
PB  - Springer Nature
KW  - SOS1 KO
KW  - SOS2 KO
KW  - SOS1/SOS2 DKO
KW  - Cell proliferation
KW  - Migration
KW  - Mitochondrial oxydative stress
KW  - Mouse Embryonic Fibroblasts
KW  - SOS1 Protein
KW  - ras GTPase-Activating Proteins
KW  - Molecular Conformation
TI  - Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs
DO  - 10.1038/onc.2016.169
T2  - Oncogene
VL  - 35
M2  - 6389
ER  -