TY  - JOUR 
AU  - Ehrmann, Alena Sophie
AU  - Quijada Álamo, Miguel
AU  - Close, Viola
AU  - Guo, Min
AU  - Carracoi, Valentina
AU  - Pérez‐Carretero, Claudia
AU  - Corchete, Luis Antonio
AU  - Friedrich, Tobias
AU  - Giaimo, Benedetto Daniele
AU  - Yosifov, Deyan Yordanov
AU  - Bloehdorn, Johannes
AU  - Rodríguez-Sánchez, Alberto
AU  - Tausch, Eugen
AU  - Schneider, Christof
AU  - Döher, Hartmut
AU  - Kietzmann, Thomas
AU  - Borggrefe, Tilman
AU  - Stilgenbauer, Stephan
AU  - Oswald, Franz
AU  - Hernández Rivas, Jesús María
AU  - Mertens, Daniel
PY  - 2025
UR  - http://hdl.handle.net/10366/172033
AB  - [EN]Aberrant active NOTCH1 signaling is a key pathogenic factor in chronic lymphocytic leukemia (CLL), detectable in half of patients and associated with disease progression. While some cases of active NOTCH1 signaling can be explained by mutations in...
LA  - eng
PB  - Springer Nature [academic journals on nature.com]
KW  - Signal Transduction
KW  - Ubiquitin Thiolesterase
KW  - Chromosome Deletion
KW  - Humans
KW  - F-Box-WD Repeat-Containing Protein 7
KW  - Cell Line, Tumor
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - Receptor, Notch1
KW  - Gene Expression Regulation, Leukemic
KW  - Ubiquitin Thiolesterase
KW  - Leukemia
KW  - Signal Transduction
KW  - Chromosome Deletion
KW  - Humans
KW  - Gene Expression Regulation
KW  - Cell Line
TI  - NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
DO  - 10.1038/s41375-025-02632-4
T2  - Leukemia
VL  - 39
M2  - 1892
ER  -