TY  - JOUR 
AU  - Álvarez Lozano, Raquel
AU  - Gajate, Consuelo
AU  - Puebla Ibáñez, María Pilar
AU  - Mollinedo García, Faustino
AU  - Medarde Agustín, Manuel
AU  - Peláez Lamamie de C. Arroyo, Rafael
PY  - 2018
SN  - 0223-5234
UR  - http://hdl.handle.net/10366/138232
AB  - [EN]Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring). Replacement of the B ring of combretastatin A-4 by a N-methyl-5-indolyl reduces tubulin...
LA  - eng
PB  - Elsevier Science Publishers (Amsterdam, Países Bajos)
KW  - N-methylindole combretastatins
KW  - Tubulin polymerization inhibiton
KW  - Cytotoxicity
KW  - Antimitotic
KW  - Microtubule disruption
KW  - P-glycoprotein
KW  - Caspasa-3 activation
TI  - Substitution at the indole 3 position yields highly potent indolecombretastatins with reduced susceptibility to MDR resistance
DO  - https://doi.org/10.1016/j.ejmech.2018.08.078
ER  -