TY  - JOUR 
AU  - Álvarez Lozano, Raquel
AU  - Aramburu Villar, Laura
AU  - Gajate, Consuelo
AU  - Vicente Blázquez, Alba
AU  - Mollinedo García, Faustino
AU  - Medarde Agustín, Manuel
AU  - Peláez Lamamie de C. Arroyo, Rafael
PY  - 2020
SN  - 0045-2068
UR  - http://hdl.handle.net/10366/148386
AB  - Colchicine site antimitotic agents typically suffer from low aqueous solubilities and are formulated as phosphate prodrugs of phenolic groups. These hydroxyl groups are the aim of metabolic transformations leading to resistance. There is an urgent...
LA  - eng
KW  - Pyridine derivatives
KW  - Combretastatins, isocombretastatins and phenstatins
KW  - Solubility
KW  - Antimitotic
KW  - Docking
TI  - Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring
DO  - 10.1016/j.bioorg.2020.103755
T2  - Bioorganic Chemistry
VL  - 98
M2  - 103755
ER  -