TY  - JOUR 
AU  - González Sánchez, Myriam
AU  - Ellahioui, Younes
AU  - Gallego, Laura
AU  - Vicente Blázquez, Alba
AU  - Alvarez, Raquel
AU  - Medarde Agustín, Manuel
AU  - Peláez Lamamie de C. Arroyo, Rafael
PY  - 2023
UR  - http://hdl.handle.net/10366/159539
AB  - [EN] The low aqueous solubility of colchicine site antimitotic agents, of which the trimethoxyphenyl (A ring) is a
heavy contributor, is a serious drawback in their clinical development. We have designed new A ring analogs
with chameleonic masked...
LA  - eng
PB  - Elsevier
KW  - Amino substituents
KW  - Tubulin
KW  - Solubility
KW  - Antimitotic
KW  - Apoptosis
KW  - Colchicine site
TI  - Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy
DO  - 10.1016/j.bioorg.2022.106282
ER  -