TY  - JOUR 
AU  - González Sánchez, Myriam
AU  - Ellahioui, Younes
AU  - Gallego, Laura
AU  - Vicente Blázquez, Alba
AU  - Álvarez, Raquel
AU  - Medarde, Manuel
AU  - Peláez Lamamie de C. Arroyo, Rafael
PY  - 2023
SN  - 0045-2068
UR  - http://hdl.handle.net/10366/163953
AB  - [EN]The low aqueous solubility of colchicine site antimitotic agents, of which the trimethoxyphenyl (A ring) is a heavy contributor, is a serious drawback in their clinical development. We have designed new A ring analogs with chameleonic masked polar...
LA  - eng
KW  - Amino substituentsTubulinSolubilityAntimitoticApoptosisColchicine site
TI  - Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy
DO  - 10.1016/J.BIOORG.2022.106282
T2  - Bioorganic Chemistry
VL  - 131
M2  - 106282
ER  -