TY  - JOUR 
AU  - Dürr, Simon L.
AU  - Bohuszewicz, Olga
AU  - Berta, Dénes
AU  - Suardiaz, Reynier
AU  - García Jambrina, Pablo
AU  - Peter, Christine
AU  - Shao, Yihan
AU  - Rosta, Edina
PY  - 2021
SN  - 2155-5435
UR  - http://hdl.handle.net/10366/166499
AB  - [EN] RNase H is a prototypical example for two-metal-ion catalysis in enzymes. An RNase H activity cleaving the ribonucleic acid (RNA) backbone of a DNA/RNA hybrid is present not only in important drug targets, such as the HIV-1 reverse transcriptase,...
LA  - eng
PB  - ACS Publications
KW  - QM/MM
KW  - Computational chemistry
TI  - The Role of Conserved Residues in the DEDDh Motif: the Proton-Transfer Mechanism of HIV-1 RNase H
DO  - 10.1021/acscatal.1c01493
T2  - ACS Catalysis
VL  - 11
M2  - 7915
ER  -