TY  - JOUR 
AU  - Lorenzo Martín, Luis Francisco
AU  - Rodríguez-Fdez, Sonia
AU  - Fabbiano, Salvatore
AU  - Abad, Antonio
AU  - García Macias, María del Carmen
AU  - Dosil, Mercedes
AU  - Cuadrado, Myriam
AU  - Robles-Valero, Javier
AU  - Bustelo, Xosé R.
PY  - 2020
UR  - http://hdl.handle.net/10366/166839
AB  - [EN]The current paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho GTPases, can be a valuable therapeutic strategy to treat Rho-dependent tumors. However, formal validation of this...
LA  - eng
PB  - Europe PMC Funders Group
KW  - Rho GTPases
KW  - Vav proteins
KW  - Rho guanosine nucleotide exchange factors
KW  - Skin tumors
KW  - Mutation
KW  - Rho Guanine Nucleotide Exchange Factors
KW  - Proto-Oncogene Proteins c-vav
KW  - Carcinogenesis
KW  - Mice
TI  - Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
DO  - 10.1038/s41388-020-1353-x
T2  - Oncogene
VL  - 39
M2  - 5098
ER  -