TY - JOUR AU - Lorenzo Martín, Luis Francisco AU - Fernández-Parejo, Natalia AU - Menacho-Márquez, Mauricio AU - Rodríguez-Fdez, Sonia AU - Robles-Valero, Javier AU - Zumalave, Sonia AU - Fabbiano, Salvatore AU - Pascual, Gloria AU - García-Pedrero, Juana M AU - Abad, Antonio AU - García Macias, María del Carmen AU - González, Nazareno AU - Lorenzano-Menna, Pablo AU - Pavón, Miguel A AU - González Sarmiento, Rogelio AU - Segrelles, Carmen AU - Paramio, Jesús M AU - Tubío, José M C AU - Rodrigo, Juan P AU - Benitah, Salvador A AU - Cuadrado, Myriam AU - Bustelo, Xosé R. PY - 2020 UR - http://hdl.handle.net/10366/166938 AB - [EN]Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-characterized. Here, we... LA - eng KW - Head and neck squamous cell carcinoma KW - RHO GTPase KW - RHO guanosine nucleotide exchange factors KW - Keratinocytes KW - Proto-Oncogene Proteins c-vav KW - Transcriptome KW - Keratinocytes KW - Epidermis KW - Cell Differentiation KW - Gene Expression Regulation KW - Signal Transduction KW - Gene Knockdown Techniques KW - Proto-Oncogene Proteins c-vav KW - Head and Neck Neoplasms KW - Cell Proliferation KW - Mice TI - VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. DO - 10.1038/s41467-020-18524-3 T2 - Nature communications VL - 11 M2 - 4788 ER -