TY - JOUR AU - Rodríguez-Fdez, Sonia AU - Lorenzo Martín, Luis Francisco AU - Fernández-Pisonero, Isabel AU - Porteiro, Begoña AU - Veyrat-Durebex, Christelle AU - Beiroa, Daniel AU - Al-Massadi, Omar AU - Abad, Antonio AU - Diéguez, Carlos AU - Coppari, Roberto AU - Nogueiras, Rubén AU - Bustelo, Xosé R. PY - 2020 UR - http://hdl.handle.net/10366/166940 AB - [EN]Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates the signaling output of the IGF1- and... LA - eng KW - Skeletal muscle KW - Rho GTPase activator KW - Insulin responsiveness KW - Proto-Oncogene Proteins c-vav KW - Muscle Cells KW - Metabolism KW - Body Composition KW - Signal Transduction KW - Adipocytes KW - Adipose Tissue KW - Proto-Oncogene Proteins c-vav KW - Mice TI - Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis. DO - 10.1038/s41467-020-19489-z T2 - Nature communications VL - 11 M2 - 5808 ER -