TY - JOUR AU - Santos Ledo, Adrián AU - Washer, Sam AU - Dhanaseelan, Tamil AU - Eley, Lorraine AU - Alqatani, Ahlam AU - Chrystal, Paul W AU - Papoutsi, Tania AU - Henderson, Deborah J AU - Chaudhry, Bill AU - Chrystal, Paul W. AU - Henderson, Deborah J. PY - 2020 UR - http://hdl.handle.net/10366/167616 AB - [EN]The planar cell polarity pathway is required for heart development and whilst the functions of most pathway members are known, the roles of the jnk genes in cardiac morphogenesis remain unknown as mouse mutants exhibit functional redundancy, with... LA - eng KW - Development KW - Zebrafish KW - Jnk KW - Mapk KW - Heart KW - laterality KW - Hand2 KW - CRISPR KW - Heart Ventricles KW - Mitogen-Activated Protein Kinase 8 KW - Animals KW - Gene Expression Regulation KW - Basic Helix-Loop-Helix Transcription Factors KW - Cells KW - Exons KW - Zebrafish Proteins KW - Alternative Splicing KW - Zebrafish KW - Cell Count TI - Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression DO - 10.1371/journal.pgen.1008782 T2 - Plos Genetics VL - 16 ER -