TY  - JOUR 
AU  - Michel, Loren
AU  - Díaz Rodríguez, María Elena
AU  - Narayan, Gopeshwar
AU  - Hernando, Eva
AU  - Murty, Vundavalli V V S
AU  - Benezra, Robert
PY  - 2004
SN  - 0027-8424
UR  - http://hdl.handle.net/10366/167924
AB  - [EN]MAD2 inhibits the anaphase-promoting complex when chromosomes are unattached to the mitotic spindle. It acts as a tumor suppressor gene because MAD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung...
LA  - eng
KW  - Mad2
KW  - Spindle checkpoint
KW  - siRNA
KW  - Mitotic catastrophy
KW  - Gene Deletion
KW  - Chromosomes
KW  - Mitosis
KW  - Transfection
KW  - Cell Cycle
KW  - Base Sequence
KW  - Calcium-Binding Proteins
KW  - Humans
KW  - Mad2 Proteins
KW  - Microscopy
KW  - Genes
KW  - Cyclin B
KW  - Cell Death
KW  - Repressor Proteins
KW  - Open Reading Frames
KW  - Cell Cycle Proteins
TI  - Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
DO  - 10.1073/pnas.0306069101
T2  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 101
M2  - 4459
ER  -