TY  - JOUR 
AU  - Hernando, Eva
AU  - Nahlé, Zaher
AU  - Juan, Gloria
AU  - Díaz Rodríguez, María Elena
AU  - Alaminos, Miguel
AU  - Hemann, Michael
AU  - Michel, Loren
AU  - Mittal, Vivek
AU  - Gerald, William
AU  - Benezra, Robert
AU  - Lowe, Scott W
AU  - Cordon-Cardo, Carlos
PY  - 2004
UR  - http://hdl.handle.net/10366/167930
AB  - [EN]Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers. However, the molecular defects underlying this trait, and whether they are a cause or a consequence of the malignant phenotype, are not...
LA  - eng
KW  - Mad2, RB inactivation, chromosome instability, aneuploidy
KW  - Mad2,
KW  - RB inactivation
KW  - Chromosome instability
KW  - Aneuploidy
KW  - DNA-Binding Proteins
KW  - Humans
KW  - Genomic Instability
KW  - Cell Line
KW  - Aneuploidy
KW  - Signal Transduction
KW  - E2F Transcription Factors
KW  - Substrate Specificity
KW  - Mice
KW  - Chromosomes
KW  - Mitosis
KW  - Retinoblastoma Protein
KW  - Cell Cycle
KW  - Gene Expression Regulation
KW  - Mad2 Proteins
KW  - Karyotyping
KW  - Carrier Proteins
KW  - Nuclear Proteins
KW  - RNA
KW  - Mutation
KW  - Immunohistochemistry
KW  - Animals
KW  - In Situ Hybridization
KW  - Cell Cycle Proteins
KW  - Transcription Factors
TI  - Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
DO  - 10.1038/nature02820
T2  - Nature
VL  - 430
M2  - 797
ER  -