TY - JOUR AU - Nieto, Blanca AU - Gaspar, Sonia G AU - Moriggi, Giulia AU - Pestov, Dimitri G AU - Bustelo, Xosé R. AU - Dosil Castro, Mercedes PY - 2020 UR - http://hdl.handle.net/10366/168969 AB - [EN]Technical problems intrinsic to the purification of preribosome intermediates have limited our understanding of ribosome biosynthesis in humans. Addressing this issue is important given the implication of this biological process in human disease.... LA - eng PB - Springer KW - Ribosome maturation KW - human ribosome KW - preribosome KW - 40S ribosomal subunit KW - pre-rRNA KW - human nucleolus KW - RNA KW - Ribosomal Proteins KW - Staining and Labeling KW - Exoribonucleases KW - Humans KW - Cell Nucleolus KW - Cell Line KW - HCT116 Cells KW - HeLa Cells KW - RNA Precursors KW - Ribosome Subunits KW - Nuclear Proteins TI - Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis DO - 10.1038/s41467-019-13990-w T2 - Nature communications VL - 11 M2 - 156 ER -