TY  - JOUR 
AU  - Fernández-Pisonero, Isabel
AU  - Clavaín, Laura
AU  - Robles Valero, Javier
AU  - Lorenzo Martín, Luis Francisco
AU  - Caloto, Rubén
AU  - Nieto, Blanca
AU  - García-Macías, Carmen
AU  - Oeste, Clara L
AU  - Sánchez Martín, Manuel Adolfo
AU  - Abad, Antonio
AU  - Hortal, Alejandro
AU  - Caballero, Dolores
AU  - González, Marcos
AU  - Dosil Castro, Mercedes
AU  - Alarcón, Balbino
AU  - Bustelo, Xosé R.
AU  - Lorenzo Martín, Luis Francisco
AU  - Oeste, Clara L.
AU  - Bustelo, Xosé R.
PY  - 2022
SN  - 2211-1247
UR  - http://hdl.handle.net/10366/169355
AB  - [EN]A missense change in RRAS2 (Gln72 to Leu), analogous to the Gln61-to-Leu mutation of RAS oncoproteins, has been identified as a long-tail hotspot mutation in cancer and Noonan syndrome. However, the relevance of this mutation for in vivo...
LA  - eng
KW  - RRAS2
KW  - ERK
KW  - RASopathies
KW  - mTORC1
KW  - T cell acute lymphoblastic leukemia
KW  - Mutation
KW  - Monomeric GTP-Binding Proteins
KW  - Animals
KW  - Humans
KW  - Oncogenes
KW  - Noonan Syndrome
KW  - Carcinogenesis
KW  - Membrane Proteins
KW  - Mice
TI  - A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
DO  - 10.1016/j.celrep.2022.110522
VL  - 38
M2  - 110522
ER  -