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Titre
A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men
Autor(es)
Sujet
Molecular medicine (genetics and pathology)
Single Nucleotide Polymorphism
Alcoholic Liver Cirrhosis
Polimorfismo genético
Cirrosis hepática
Fecha de publicación
2016
Éditeur
Public Library of Science (New York)
Citación
Novo-Veleiro, I., Cieza-Borrella, C., Pastor, I., Chamorro A.-J., Laso, F.-J., González-Sarmiento, R., et al. (2016) A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. PLoS ONE 11(12): e0168685.
Resumen
[EN[Genetic polymorphisms in the RAS gene family are associated with different diseases,
which may include alcohol-related disorders. Previous studies showed an association of the
allelic variant rs26907 in RASGRF2 gene with higher alcohol intake. Additionally, the
rs61764370 polymorphism in the KRAS gene is located in a binding site for the let-7 micro-
RNA family, which is potentially involved in alcohol-induced inflammation. Therefore, this
study was designed to explore the association between these two polymorphisms and susceptibility
to alcoholism or alcoholic liver disease (ALD).
URI
ISSN
1932-6203
DOI
10.1371/journal.pone.0168685
Versión del editor
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