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Título
Development and application of bioinformatic methods to analyze genome-wide expression and survival data from cancer patients
Otros títulos
Desarrollo y aplicación de métodos bioinformáticos al análisis de datos de expresión genómica y datos de supervivencia de pacientes con cáncer
Autor(es)
Director(es)
Palabras clave
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Bioinformática
Genómica del cáncer
Clasificación UNESCO
2302.04 Genética Bioquímica
Fecha de publicación
2019-07
Resumen
[EN] The development of robust omic technologies (genomics, transcriptomics, proteomics,
etc) to generate and understand genome-wide alterations is already having an impact
on health care, with a particular relevance on cancer and oncology. Within the
current context of Personalised Medicine, Precision Medicine and Genomic Medicine
(Roden and Tyndale, 2013), modern cancer research has to be done considering an
adecuate use of the large-scale data derived from these new omic technologies. Some
of these technologies, such as transcriptomic expression pro ling, have been already
applied to thousands of human samples (see public database GEO (NCBI, 2019)),
and provide information about the expression status of all the known genes in the
analised individuals. In order to be useful and applicable to medical research, such
omic data should be integrated with the corresponding clinical data using adequate
computational and bioinformatic tools and methods. This is a main framework
where the current Doctoral Thesis work is proposed.
URI
DOI
10.14201/gredos.140370
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