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Título
Diastereoselective synthesis of chiral 1,3-cyclohexadienals
Autor(es)
Palabras clave
Organocatalysis
Asymmetric synthesis
Química orgánica
Organic chemistry
Chirality
Quiralidad
Organocatálisis
Fecha de publicación
2018
Editor
Andrew C. Marr, Queen's University Belfast, UNITED KINGDOM
Citación
Urosa A, Tobal IE, de la Granja ÁP, Capitán MC, Moro RF, Marcos IS, et al. (2018) Diastereoselective synthesis of chiral 1,3-cyclohexadienals. PLoS ONE 13(2): e0192113. https://doi.org/10.1371/journal.pone.0192113
Resumen
[EN] A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The
organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes
with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst
provides easy and stereocontrolled access to the cyclohexadienal backbone.
This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals
and extra extended conjugation compounds in a simple manner.
URI
DOI
10.1371/journal.pone.0192113
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