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Titolo
Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E, and Revised Structure for Corticin A
Autor(es)
Soggetto
Grupo de Investigación en Biodiversidad, Sistemática y Conservación de Plantas Vasculares y Hongos
Terana coerulea
Terana caerulea
Corticium caeruleum
Neolignans
Terphenyls
Corticin
Thelephoric acid
Cytotoxic activity
Fungus
Navarra
Fecha de publicación
2017
Citación.
Maisterra, M., Castro, M. Á., Muñoz-Centeno, L. M., Calhelha, R. C., Ferreira, I. C., & García, P. A. (2017). Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E, and Revised Structure for Corticin A. Natural product communications, 12(5), 1934578X1701200513.
Abstract
[EN] The cobalt crust fungus Terana coerulea (Phanerochaetaceae family) was selected for a bio-guided study after an ethnobotanical survey at the Irati’s Forest
(Navarra, Spain) for its local use as antibiotic. Six extracts of increasing polarity, from hexane to hot water, were obtained from powdered dry fungi and tested
for cytotoxicity against four human tumour cell lines and one non-tumour primary cell culture. From the most cytotoxic, EtOAc extract, we isolated and
identified three terphenyl neolignans: two of them new natural products, named corticins D and E, and one previously described as corticin A, whose earlier
structure has been revised. Their structural elucidation and biological evaluation as cytotoxic agents are described.
URI
ISSN
1934-578X
DOI
10.1177/1934578X1701200513
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