Compartir
Titre
Deviance detection in auditory subcortical structures: what can we learn from neurochemistry and neural connectivity?
Autor(es)
Sujet
Auditory
Stimulus-specific adaptation
Mismatch negativity
Non-lemniscal
Inhibition
Deviance detection
Clasificación UNESCO
3213.08 Neurocirugía
Fecha de publicación
2015
Éditeur
Cell and Tissue Research
Citación
Duque, A. ; Ayala, Y.A. ; Sánchez Malmierca, M. (2015). Deviance detection in auditory sucortical structures: what can we learn from neurochemistry and neural connectivity?. Cell and Tissue Research, 361(1), pp. 215-232. doi:10.1007/s00441-015-2134-7
Résumé
[EN] A remarkable ability of animals that is critical for survival is to detect and respond to to unexpected stimuli in an ever-changing world. Auditory neurons that show stimulusspecific adaptation (SSA), i.e., a decrease in their response to frequently occurring stimuli while maintaining responsiveness when different stimuli are presented, might participate in the coding of deviance occurrence. Traditionally, deviance detection is measured by the mismatch negativity (MMN) potential in studies of evoked local field potentials.We present a review of the state-of-the-art of SSA in auditory subcortical nuclei, i.e., the inferior colliculus and medial geniculate body of the thalamus, and link the differential receptor distribution
and neural connectivity of those regions in which extreme SSA has been found. Furthermore, we review both SSA and MMN-like responses in auditory and non-auditory areas that exhibit multimodal sensitivities that we suggest conform to a distributed network encoding for deviance detection. The understanding
of the neurochemistry and response similarities across these different regions will contribute to a better understanding of the neural mechanism underlying deviance detection.
URI
ISSN
0302-766X
DOI
10.1007/s00441-015-2134-7
Versión del editor
Aparece en las colecciones