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Título
Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus
Autor(es)
Materia
Cortical inputs
Brainstem inputs
SSA
non-SSA neurons
Inferior colliculus
Clasificación UNESCO
2490 Neurociencias
Fecha de publicación
2015
Editor
Scientific Reports
Citación
Ayala,Y.A. ; Udeh, A. [et al.] (2015). Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus. Scientific Reports, 5(1), pp. 1-17. doi: 10.1038/srep10383
Resumen
[EN] In an ever changing auditory scene, change detection is an ongoing task performed by the auditory
brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA)
may contribute to this process. Those neurons adapt to frequent sounds while retaining their
excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part
of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare
sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source
of projections with the physiological response. SSA neurons were confined to the non-lemniscal
subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central
nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory
cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary,
the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These
findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that
are populated by SSA neurons enabling them to compare top-down signals with incoming sensory
information from lower areas.
URI
DOI
10.1038/srep10383
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