Compartir
Título
Stimulus-specific adaptation in the inferior colliculus: The role of excitatory, inhibitory and modulatory inputs
Autor(es)
Assunto
MMN
SSA
GABA
Glutamate
Acetylcholine
Auditory
Clasificación UNESCO
2490 Neurociencias
3205.07 Neurología
Fecha de publicación
2016
Editor
Biological Psychology
Citación
Aguilar Ayala, A. ; Pérez González, D. ; Sánchez Malmierca, M. (2016). Stimulus-specific adaptation in the inferior colliculus: The role of excitatory, inhibitory and modulatory inputs. Biological Psychology 116, pp. 10-22. doi: 10.1016/j.biopsycho.2015.06.016
Resumen
[EN] Patients suffering from pathologies such as schizophrenia, depression or dementia exhibit cognitive impairments, some of which can be reflected in event-related potential (ERP) measurements as the mismatch negativity (MMN). The MMN is one of the most commonly used ERPs and provides an elec-trophysiological index of auditory change or deviance detection. Moreover, MMN has been positioned as a potentially promising biomarker candidate for the diagnosis and prediction of the outcome of schizophrenia. Dysfunction of neural receptors has been linked to the etiopathology of schizophrenia or the induction of psychophysiological anomalies similar to those observed in schizophrenia. Stimulus-specific adaptation (SSA) is a neural mechanism that contributes to the upstream processing of auditory change detection. Auditory neurons that exhibit SSA specifically adapttheir response to repetitive sounds but maintain their excitability to respond to rare ones. Thus, by studying the role of neuronal receptors on SSA, we can contribute to detangle the cellular bases ofthe impairments in deviance processing occurring in mental pathologies. Here, we review the current knowledge on the effect of GABAA-mediated inhibition and themodulation of acetylcholine on SSAin the inferior colliculus, and we add unpublished original data obtained blocking glutamate receptors. We found that the blockade of GABAA and glutamate receptors mediates an overall increase or decrease of the neural response, respectively, while acetylcholine affects only the response to the repetitive sounds. These results demonstrate that GABAergic, glutamatergic and cholinergic receptors play different and complementary roles on shaping SSA.
URI
ISSN
0301-0511
DOI
10.1016/j.biopsycho.2015.06.016
Versión del editor
Aparece en las colecciones