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Título
Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions
Autor(es)
Materia
Sympathetic system
Ventrolateral medulla
Brainstem
GABAergic signals
Hypertension
Metabolic syndrome
Diabetes
Liver
Adipose tissue
Thermogenesis
Clasificación UNESCO
2302.21 Biología Molecular
6310.03 Enfermedad
3206 Ciencias de la Nutrición
2411 Fisiología Humana
Fecha de publicación
2019
Editor
Europe PMC Funders Group
Citación
Lorenzo Martín, L.F., et al. (2019). Vagal afferents contribute to sympathoexcitation–driven metabolic dysfunctions. Journal of Endocrinology, 240, pp. 183-496.
Resumen
[EN] Multiple crosstalk between peripheral organs and the nervous system are required to maintain
physiological and metabolic homeostasis. Using Vav3–deficient mice as a model for chronic
sympathoexcitation–associated disorders, we report here that afferent fibers of the hepatic branch
of the vagus nerve are needed for the development of the peripheral sympathoexcitation,
tachycardia, tachypnea, insulin resistance, liver steatosis, and adipose tissue thermogenesis present
in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral
medulla, a sympathoregulatory brainstem center hyperactive in Vav3 –/– mice. Vagal afferent inputs
are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other
peripheral sympathoexcitation–associated disorders sparing metabolic alterations in liver.
URI
ISSN
0022-0795
DOI
10.1530/JOE-18-0623
Versión del editor
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