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Titel
Specialized cutaneous Schwann cells initiate pain sensation
Autor(es)
Schlagwort
Schwann Cells
Dolor
Estímulo doloroso
Nervio
Clasificación UNESCO
2403 Bioquímica
2490 Neurociencias
2411 Fisiología Humana
Fecha de publicación
2019-08-16
Resumen
An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory nerve endings in the skin. We discovered a specialized cutaneous glial cell type with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal and mechanical sensitivity. We demonstrate a direct excitatory functional connection to sensory neurons and provide evidence of a previously unknown organ that has an essential physiological role in sensing noxious stimuli. Thus, these glial cells, which are intimately associated with unmyelinated nociceptive nerves, are inherently mechanosensitive and transmit nociceptive information to the nerve.
URI
ISSN
0036-8075
DOI
10.1126/science.aax6452
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