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Título
Impact of phosphoproteomics in the translation of kinase-targeted therapies
Autor(es)
Materia
Biomarkers
Cancer
Kinase inhibitors
Phosphoproteomics
Technology
Fecha de publicación
2017-03
Editor
Wiley
Citación
Casado, P., Hijazi, M., Britton, D., & Cutillas, P. R. (2017). Impact of phosphoproteomics in the translation of kinase‐targeted therapies. Proteomics, 17(6), 1600235. https://doi.org/10.1002/pmic.201600235
Resumen
[EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndromes. Phosphoproteomics is a technique that measures the products of kinase activities and, with the appropriate bioinformatics techniques, the methodology can also provide measures of kinase pathway activation and network circuitry. Hence, due to recent technological advantages, LC-MS-based quantitative phosphoproteomics provides relevant information for the design and implementation of kinase inhibitor based therapies. Here, we review how phosphoproteome profiling is being used in translational research as a means to identify drug targets and biomarkers for personalizing therapies based on kinase inhibitors.
URI
ISSN
1615-9853
DOI
10.1002/pmic.201600235
Versión del editor
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