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Titolo
Different tonotopic regions of the lateral superior olive receive a similar combination of afferent inputs
Autor(es)
Soggetto
Lateral superior olive
Ventral cochlear nucleus
Medial nucleus of the trapezoid body
Ventral nucleus of the trapezoid body
Spherical bushy cells
Planar multipolar neurons
Auditory
Biotinylated dextran amine (BDA)
Rat
Clasificación UNESCO
2410.09 Neuroanatomía Humana
2411.13 Fisiología de la Audición
Fecha de publicación
2016-08-01
Editore
Wiley
Citación
Gómez‐Álvarez, M., & Saldana, E. (2016). Different tonotopic regions of the lateral superior olive receive a similar combination of afferent inputs. Journal of Comparative Neurology, 524(11), 2230-2250. https://doi.org/10.1002/cne.23942
Resumen
[EN]The mammalian lateral superior olive (LSO) codes disparities in the intensity of the sound that reaches the two ears by integrating ipsilateral excitation and contralateral inhibition, but it remains unclear what particular neuron types convey acoustic information to the nucleus. It is also uncertain whether the known conspicuous morphofunctional differences and gradients along the tonotopic axis of the LSO relate to qualitative and/or quantitative regional differences in its afferents. To clarify these issues, we made small, single injections of the neuroanatomical tracer biotinylated dextran amine (BDA) into different tonotopic regions of the LSO of albino rats and analyzed the neurons labeled retrogradely in brainstem auditory nuclei. We demonstrate that the LSO is innervated tonotopically by four brainstem neuron types: spherical bushy cells and planar multipolar neurons of the ipsilateral ventral cochlear nucleus, principal neurons of the ipsilateral medial nucleus of the trapezoid body, and small multipolar neurons of the contralateral ventral nucleus of the trapezoid body. Unexpectedly, the proportion of labeled neurons of each type was virtually identical in all cases, thus indicating that all tonotopic regions of the LSO receive a similar combination of inputs. Even more surprisingly, our data also suggest that the representation of frequencies in the LSO differs from that of the nuclei that innervate it: compared to the latter nuclei, the LSO seems to possess a relatively larger portion of its volume devoted to processing frequencies in the lower-middle part of the spectrum, and a relative smaller portion devoted to higher frequencies. J. Comp. Neurol. 524:2230-2250, 2016. © 2015 Wiley Periodicals, Inc.
URI
ISSN
0021-9967
DOI
10.1002/cne.23942
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