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Titolo
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Autor(es)
Soggetto
Cell Cycle
Mitosis
Phosphatases
Transcription
Clasificación UNESCO
2415 Biología Molecular
2407 Biología Celular
2302 Bioquímica
Fecha de publicación
2011
Editore
Nature Research
Citación
Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D. G., Sacristán, M. P., & Malumbres, M. (2011). Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Scientific reports, 1(1), 189. doi:10.1038/srep00189
Resumen
[EN]Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle.
Descrizione
Article number: 189 (2011)
URI
DOI
10.1038/srep00189
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