Mostrar el registro sencillo del ítem
dc.contributor.author | Guillamot, María | |
dc.contributor.author | Manchado, Eusebio | |
dc.contributor.author | Chiesa, Massimo | |
dc.contributor.author | Gómez-López, Gonzalo | |
dc.contributor.author | Pisano, David G. | |
dc.contributor.author | Sacristán Martín, María Paz | |
dc.contributor.author | Malumbres, Marcos | |
dc.date.accessioned | 2024-02-19T17:20:13Z | |
dc.date.available | 2024-02-19T17:20:13Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D. G., Sacristán, M. P., & Malumbres, M. (2011). Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Scientific reports, 1(1), 189. doi:10.1038/srep00189 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10366/155919 | |
dc.description | Article number: 189 (2011) | es_ES |
dc.description.abstract | [EN]Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Research | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cell Cycle | es_ES |
dc.subject | Mitosis | es_ES |
dc.subject | Phosphatases | es_ES |
dc.subject | Transcription | es_ES |
dc.title | Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publishversion | https://www.nature.com/articles/srep00189 | es_ES |
dc.subject.unesco | 2415 Biología Molecular | es_ES |
dc.subject.unesco | 2407 Biología Celular | es_ES |
dc.subject.unesco | 2302 Bioquímica | es_ES |
dc.identifier.doi | 10.1038/srep00189 | |
dc.relation.projectID | AICR #08-0188 | es_ES |
dc.relation.projectID | BFU2008-04293 | es_ES |
dc.relation.projectID | SAF2009-07973 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2045-2322 | |
dc.journal.title | Scientific Reports | es_ES |
dc.volume.number | 1 | es_ES |
dc.issue.number | 1 | es_ES |
dc.page.initial | 1 | es_ES |
dc.page.final | 7 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |