dc.contributor.author | Sacristán Martín, María Paz | |
dc.contributor.author | Vestal, D. J. | |
dc.contributor.author | Dours‐Zimmermann, M. T. | |
dc.contributor.author | Ranscht, B. | |
dc.date.accessioned | 2024-04-04T11:14:12Z | |
dc.date.available | 2024-04-04T11:14:12Z | |
dc.date.issued | 1993 | |
dc.identifier.citation | Sacristan, M. P., Vestal, D. J., Dours‐Zimmermann, M. T., & Ranscht, B. (1993). T‐Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T‐cadherin and N‐cadherin. Journal of neuroscience research, 34(6), 664-680. | es_ES |
dc.identifier.issn | 0360-4012 | |
dc.identifier.uri | http://hdl.handle.net/10366/157116 | |
dc.description.abstract | [EN] Cadherins are integral membrane glycoproteins that mediate calcium-dependent, hornophilic cell-cell adhesion and are implicated in controlling tissue morphogenesis. T-cadherin is anchored to the membrane through a glycosyl phosphatidylinositol and expressed in a restricted pattern in developing embryos. We report here the molecular and functional characterization of the T-cadherin isoform, T-cadherin 2 (Tcad-2) and the expression of the corresponding mRNA. Tcad-2 cDNA differs in its 3’ nucleotide sequence from T-cadherin cDNA and encodes a protein in which the carboxy terminal Leu of T-cadherin is substituted by Lys and extended by the amino acids SerPheProTyrVal. By RNase protection, mRNAs encoding the T-cadherin isoforms are coexpressed in heart, muscle, liver, skin, somites, and in neural tissue. Many tissues contain both T-cadherin and Tcad-2 mRNAs in conjunction with N-cadherin transcripts, and T-cadherins and N-cadherin proteins are coexpressed on the surface of individual neurons in vitro. Expression in Chinese hamster ovary cells (CHO) revealed that Tcad-2 is a glycosyl phosphatidylinositol-anchored membrane protein that functions in calcium-dependent, homophilic cell adhesion. The identification of a functional T-cadherin isoform and the coexpression of T-cadherins and N-cadherin by individual cells suggest that specific adhesive interactions of embryonic cells may involve a complex interplay between multiple cadherins. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley Online Library | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Cell adhesion molecule | es_ES |
dc.subject | Calcium dependence | es_ES |
dc.subject | Homophilic binding | es_ES |
dc.subject | T-cadherin isoforms | es_ES |
dc.title | T‐Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T‐cadherin and N‐cadherin | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publishversion | https://doi.org/10.1002/jnr.490340610 | es_ES |
dc.subject.unesco | 2302 Bioquímica | es_ES |
dc.subject.unesco | 2407 Biología Celular | es_ES |
dc.subject.unesco | 2415 Biología Molecular | es_ES |
dc.identifier.doi | 10.1002/jnr.490340610 | |
dc.relation.projectID | National Institute of Health (HD25938) | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1097-4547 | |
dc.journal.title | Journal of Neuroscience Research | es_ES |
dc.volume.number | 34 | es_ES |
dc.issue.number | 6 | es_ES |
dc.page.initial | 664 | es_ES |
dc.page.final | 680 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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