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Título
Genome-wide association studies (GWAS) and their importance in asthma
Autor(es)
Materia
Asthma
Epigenetics
Genome-wide association studies (GWAS)
Genomics
Next generation sequencing
Clasificación UNESCO
3207.01 Alergias
2409 Genética
Fecha de publicación
2015-11
Editor
Elsevier
Citación
García-Sánchez A, Isidoro-García M, García-Solaesa V, Sanz C, Hernández-Hernández L, Padrón-Morales J, Lorente-Toledano F, Dávila I. Genome-wide association studies (GWAS) and their importance in asthma. Allergol Immunopathol (Madr). 2015 Nov-Dec;43(6):601-8. doi: 10.1016/j.aller.2014.07.004. Epub 2014 Nov 26. PMID: 25433770.
Resumen
[EN] Asthma is a complex disease determined by the interaction of different genes and environmental factors. The first genetic investigations in asthma were candidate gene association studies and linkage studies. In recent years research has focused on association studies that scan the entire genome without any prior conditioning hypothesis: the so-called genome-wide association studies (GWAS). The first GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1). None of these genes would have been selected in a classical genetic association study since it was not known they could be implicated in asthma. To date, a number of GWAS studies in asthma have been made, with the identification of about 1000 candidate genes. Coordination of the different research groups in international consortiums and the application of new technologies such as new generation sequencing will help discover new implicated genes and improve our understanding of the molecular mechanisms underlying the disease.
URI
ISSN
0301-0546
DOI
10.1016/j.aller.2014.07.004
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