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Titel
Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation
Autor(es)
Schlagwort
Neuronas
Apoptosis
Mitocondrias
Especies reactivas de oxígeno
ROS
Glutamato
Potencial de membrana
Cerebelare
Free radicals
Glutamate
Glutathione
Mitochondria
Neurodegeneration
Neuroprotection
Fecha de publicación
2005
Verlag
Blackwell Publishing Ltd. (Oxford, Reino Unido)
Citación
García, O., Almeida Parra, A., Massieu, L., Bolaños Hernández, J.P. (2005). Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation. "Journal of Neurochemistry", 92, 183-190.
Resumen
La activación de los receptores de glutamato, conseguida por inhibición de su transporte provocando incremento de las concentraciones extracelulares del aminoácido, causa un incremento de la velocidad del transporte electrónico a través de la cadena respiratoria mitocondrial en cultivos de neuronas de cerebelo. Esta activación tiene como fin mantener el potencial de membrana mitocrondrial en las neuronas, por lo que se trata de un mecanismo neuroprotector. It is thought that the combination of extracellular glutamate accumulation and mitochondrial damage is involved in neuronal death associated with brain ischemia and hypoglycemia, and some neurodegenerative diseases such as Huntington s disease. However, the mechanism whereby those two factors interact together to trigger neurodegeneration in this and other neurodegenerative disorders is still elusive. Here, we have addressed this issue using a model of mild and sustained accumulation of extracellular glutamate in cerebellar cultured neurons, which are mostly glutamatergic and commonly used to study glutamate neurotoxicity.
URI
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