TY  - JOUR 
AU  - Baltanás, Fernando C.
AU  - Garcia Navas, Rosula Mercedes
AU  - Rodríguez-Ramos, Pablo
AU  - Calzada, Nuria
AU  - Cuesta Apausa, Cristina
AU  - Borrajo Sánchez, Javier
AU  - Fuentes Mateos, Rocío
AU  - Olarte-San Juan, Andrea
AU  - Vidaña, Nerea
AU  - Castellano Sánchez, María Esther
AU  - Santos de Dios, Eugenio Miguel
PY  - 2023
UR  - http://hdl.handle.net/10366/156736
AB  - [EN]The impact of genetic ablation of SOS1 or SOS2 is evaluated in a murine model of KRASG12D-driven lung adenocarcinoma (LUAD). SOS2 ablation shows some protection during early stages but only SOS1 ablation causes significant, specific long term...
LA  - eng
KW  - Adenocarcinoma
KW  - Adenocarcinoma of Lung
KW  - Cancer-Associated Fibroblasts
KW  - Lung Neoplasms
KW  - Animals
KW  - Humans
KW  - Mice
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Tumor Microenvironment
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Tumor Microenvironment
KW  - Lung Neoplasms
KW  - Adenocarcinoma
KW  - Animals
KW  - Humans
KW  - Mice
TI  - Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinoma
DO  - 10.1038/s41467-023-41583-1
T2  - Nature Communications
VL  - 14
M2  - 5856
ER  -