[EN] Multiple myeloma (MM) is a hematologic neoplasm characterized by the proliferation of
clonal plasma cells (PCs) in the bone marrow (BM). The substitution of normal BM cells
by MM cells results in cytopenias responsible, among other factors, for the
immunodeficiency observed in these patients, and also in the production of monoclonal
immunoglobulins (Igs) that can lead to renal failure. Other symptoms as hypercalcemia
and osteolysis are direct consequences of the interaction of malignant PCs with the BM
microenvironment.
