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dc.contributor.advisor | Garayoa Berrueta, Mercedes | es_ES |
dc.contributor.advisor | Ocio San Miguel, Enrique M. | es_ES |
dc.contributor.advisor | Rivas Sanz, Javier de las | es_ES |
dc.contributor.advisor | González Díaz, Marcos | es_ES |
dc.contributor.author | Algarín, Esperanza Macarena | |
dc.date.accessioned | 2020-11-25T16:45:47Z | |
dc.date.available | 2020-11-25T16:45:47Z | |
dc.date.issued | 2020-06 | |
dc.identifier.uri | http://hdl.handle.net/10366/144179 | |
dc.description.abstract | [EN] Multiple myeloma (MM) is a hematologic neoplasm characterized by the proliferation of clonal plasma cells (PCs) in the bone marrow (BM). The substitution of normal BM cells by MM cells results in cytopenias responsible, among other factors, for the immunodeficiency observed in these patients, and also in the production of monoclonal immunoglobulins (Igs) that can lead to renal failure. Other symptoms as hypercalcemia and osteolysis are direct consequences of the interaction of malignant PCs with the BM microenvironment. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Tesis y disertaciones académicas | es_ES |
dc.subject | Universidad de Salamanca (España) | es_ES |
dc.subject | Tesis Doctoral | es_ES |
dc.subject | Academic dissertations | es_ES |
dc.subject | Hematología | es_ES |
dc.subject | Mieloma múltiple | es_ES |
dc.subject.mesh | Multiple Myeloma | * |
dc.title | Resumen de tesis. Preclinical evaluation of BH3-mimetics targeting MCL-1 (S63845) and BCL-2 (venetoclax) in multiple myeloma | es_ES |
dc.title.alternative | Preclinical evaluation of BH3-mimetics targeting MCL-1 (S63845) and BCL-2 (venetoclax) in multiple myeloma | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
dc.subject.unesco | 3207.08 Hematología | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject.decs | mieloma múltiple | * |