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Título
Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer
Otros títulos
The MEK5/ERK5 pathway in lung and ovarian cancer
La vía de MEK5/ERK5 en cáncer de
pulmón y ovario
Autor(es)
Director(es)
Materia
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Ovarios
Pulmón
Cáncer
Clasificación UNESCO
6310.03 Enfermedad
Fecha de publicación
2021
Resumen
[EN] There is an obvious clinical need for unveiling novel pathophysiological mechanisms
underlying lung and ovarian tumors that could foster the development of new targeted
therapies and which, in turn, may positively impact the outcome of patients suffering from
these severe diseases.
Considering all the bibliographic precedents and the previous expertise of our laboratory on
the study of the MEK5/ERK5 signaling pathway, the main objectives of this doctoral thesis
project were:
To develop a mouse model genetically engineered to express a constitutively active
form of MEK5 to answer the question whether the sole activation of this signaling route
promotes tumorigenesis.
To study the functional relevance of the MEK5/ERK5 route in ovarian cancer.
URI
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