Resumen de tesis. The MEK5/ERK5 pathway in lung and ovarian cancer

Abstract

[EN] There is an obvious clinical need for unveiling novel pathophysiological mechanisms underlying lung and ovarian tumors that could foster the development of new targeted therapies and which, in turn, may positively impact the outcome of patients suffering from these severe diseases. Considering all the bibliographic precedents and the previous expertise of our laboratory on the study of the MEK5/ERK5 signaling pathway, the main objectives of this doctoral thesis project were: To develop a mouse model genetically engineered to express a constitutively active form of MEK5 to answer the question whether the sole activation of this signaling route promotes tumorigenesis. To study the functional relevance of the MEK5/ERK5 route in ovarian cancer.