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Título
Biological Properties of Solid Free Form Designed Ceramic Scaffolds with BMP-2: In Vitro and In Vivo Evaluation
Autor(es)
Materia
Solid Free Form
Ceramic scaffolds
Osteointegration
BMP-2
Clasificación UNESCO
3313 Tecnología E Ingeniería Mecánicas
3312.03 Materiales Cerámicos
Fecha de publicación
2012
Editor
Public Library of Science
Citación
Abarrategi A, Moreno-Vicente C, Martínez-Vázquez FJ, Civantos A, Ramos V, Sanz-Casado JV, et al. (2012) Biological Properties of Solid Free Form Designed Ceramic Scaffolds with BMP-2: In Vitro and In Vivo Evaluation. PLoS ONE 7(3): e34117. https://doi.org/10.1371/journal.pone.0034117
Resumen
[EN]Porous ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials. Solid free form (SFF) fabrication methods allow fabrication of ceramic scaffolds with fully controlled pore architecture, which opens new perspectives in bone tissue regeneration materials. However, little experimentation has been performed about real biological properties and possible applications of SFF designed 3D ceramic scaffolds. Thus, here the biological properties of a specific SFF scaffold are evaluated first, both in vitro and in vivo, and later scaffolds are also implanted in pig maxillary defect, which is a model for a possible application in maxillofacial surgery. In vitro results show good biocompatibility of the scaffolds, promoting cell ingrowth. In vivo results indicate that material on its own conducts surrounding tissue and allow cell ingrowth, thanks to the designed pore size. Additional osteoinductive properties were obtained with BMP-2, which was loaded on scaffolds, and optimal bone formation was observed in pig implantation model. Collectively, data show that SFF scaffolds have real application possibilities for bone tissue engineering purposes, with the main advantage of being fully customizable 3D structures
URI
DOI
10.1371/JOURNAL.PONE.0034117
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