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Titolo
Genomic profiling of sporadic liver metastatic colorectal cancer
Autor(es)
Soggetto
Genetic alterations
Genetic heterogeneity
Genome profile
Liver metastasis
Sporadic colorectal cancer
Fecha de publicación
2021
Editore
Elsevier
Citación
González-González M, Gutiérrez ML, Sayagués JM, Muñoz-Bellvís L, Orfao A. Genomic profiling of sporadic liver metastatic colorectal cancer. Semin Cancer Biol. 2021 Jun;71:98-108. https://doi.org/10.1016/j.semcancer.2020.05.013. Epub 2020 May 30. PMID: 32485312.
Resumen
[EN]Sporadic colorectal cancer (sCRC) is the third leading cause of cancer death in the Western world. Approximately, a quarter of sCRC patients present metastatic dissemination at the moment of diagnosis, the liver being the most frequently affected organ. Additionally, this group of CRC patients is characterized by a worse prognosis. In the last decades, significant technological developments for genome analysis have fostered the identification and characterization of genetic alterations involved in the pathogenesis of sCRC. However, genetic alterations involved in the metastatic process through which tumor cells are able to colonize other tissues with a different microenvironment, still remain to be fully identified. Here, we review current knowledge about the most relevant genomic alterations involved in the liver metastatic process of sCRC, including detailed information about the genetic profile of primary colorectal tumors vs. their paired liver metastases.
URI
ISSN
1044-579X
DOI
10.1016/j.semcancer.2020.05.013
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