Compartir
Título
Validation of a compartmental model to predict drug release from porous structures produced by ScCO2 techniques
Autor(es)
Materia
Release kinetics
Compartmental model
Drug delivery systems
ScCO 2 structures
Clasificación UNESCO
3303 Ingeniería y Tecnología Químicas
Fecha de publicación
2023
Editor
Elsevier
Resumen
[EN]A global release model is proposed to study the drug release from porous materials for pharmaceutical applications. This model is defined by implementing a compartmental model where the release profile could be explained as the combination of mass transfer phenomena through three compartments as well as a desorption process or dissolution process from the support. This model was validated with five different systems produced with supercritical CO 2 (aerogels, membranes, and fibers), showing different release processes. Numerical results indicate that this compartmental approach can be useful to determine adsorption and desorption constants as well as mass transfer resistances within the material. Likewise, this model can predict lag phases and imbibition phenomena. Therefore, the development of compartmental models can be an alternative to traditional models to successfully predict the drug profile of porous materials, achieving a complete understanding of the involved phenomena regardless of the material characteristics.
URI
ISSN
0928-0987
DOI
10.1016/j.ejps.2022.106325
Versión del editor
Colecciones
- ABIQ. Artículos [6]