Título
A modular approach to trim cellular targets in anticancer drug discovery
Autor(es)
Palabras clave
Phenotypic Drug Discovery
Antitumor agents
Cell cycle
Mitotic arrest
Structure–activity relationships
Clasificación UNESCO
2302 Bioquímica
2302.06 Quimioterapia
2407 Biología Celular
Fecha de publicación
2011-11-15
Citación
Ríos-Luci, C., Domínguez-Kelly, R., León, L. G., Díaz-Rodríguez, E., Freire, R., Pandiella, A., ... & Padrón, J. M. (2011). A modular approach to trim cellular targets in anticancer drug discovery. Bioorganic & medicinal chemistry letters, 21(22), 6641-6645.
Resumen
[EN]A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.
URI
ISSN
0960-894X
DOI
10.1016/j.bmcl.2011.09.069
Versión del editor
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