Oxidative eustress regulates insulin signaling and promotes GLUT4-mediated glucose uptake in insulin-resistant skeletal muscle fibres

Martín-Prieto, Eva; Catalano Iniesta, Leonardo; Fernández Puente, Escarlata; Americo-Da-Silva, Luan; Montaña Collao, Paula; Lobos, Pedro; Llanos, Paola; Palomero Labajos, Jesús

doi:10.1016/j.freeradbiomed.2026.05.071

Título

Oxidative eustress regulates insulin signaling and promotes GLUT4-mediated glucose uptake in insulin-resistant skeletal muscle fibres

Autor(es)

Martín-Prieto, Eva

Catalano Iniesta, Leonardo

Fernández Puente, Escarlata

Americo-Da-Silva, Luan

Montaña Collao, Paula

Lobos, Pedro

Llanos, Paola

Palomero Labajos, Jesús

Palabras clave

RONS

Resistencia a la insulina

Estrés oxidativo

Oxidative eustress

insulin-resistant

Clasificación UNESCO

3209 Farmacología

Fecha de publicación

2026

Editor

Elsevier

Citación

Martín-Prieto, E., Catalano-Iniesta, L. A., Fernández-Puente, E., Americo-Da-Silva, L., Montaña-Collao, P., Lobos, P., Llanos, P., y Palomero, J. (2026). Oxidative eustress regulates insulin signaling and promotes GLUT4-mediated glucose uptake in insulin-resistant skeletal muscle fibres. Free Radical Biology and Medicine, 249, S15. https://doi.org/10.1016/j.freeradbiomed.2026.05.071

Resumen

[EN]The document focuses on how oxidative eustress (a moderate and beneficial level of reactive species) acts as an alternative regulatory mechanism to trigger GLUT4 trafficking and restore glucose uptake within insulin-resistant skeletal muscle.

URI

https://hdl.handle.net/10366/171922

ISSN

0891-5849

DOI

10.1016/j.freeradbiomed.2026.05.071

Versión del editor

https://doi.org/10.1016/j.freeradbiomed.2026.05.071

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